Tamoxifen Citrate 25mg x 30ml


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Tamoxifen Citrate is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, hence tamoxifen citrate may be characterized as a mixed agonist/antagonist. It has been the standard endocrine (anti-estrogen) therapy for hormone receptor-positive early breast cancer in pre-menopausal women, although aromatase inhibitors have been proposed. Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen Citrate is metabolized into compounds that also bind to the estrogen receptor but do not activate it.

The effect of an antiestrogen, Tamoxifen Citrate on the differential follicular counts in the domestic pigeon Columba livia is investigated. 250µg/tamoxifen citrate/0.2 ml olive oil/ day (7 injections) were administered to female pigeons during preincubation phase. The weight of the ovary, oviduct and length of the oviduct were noted at autopsy. The number of follicles at different developmental stages was counted and classified depending on their diameter. There was a significant decrease in the length of the oviduct and weight of the ovary and oviduct in tamoxifen citrate treated pigeons. There was a significant increase in the total number of normal and atretic follicles and only Stage I to Stage III follicles were found in the tamoxifen citrate treated pigeons. This study suggests that, estrogen is needed for the maintenance of dominant yolky follicles. The growth of previtellogenic follicles, stage I does not seem to be dependent upon estrogen. A significant increase in the number of Stage I previtellogenic follicles in tamoxifen citrate treated pigeons suggests that the recruitment of these follicles might be under inhibitory/ regulatory influence of dominant yolky follicles in the ovary.

CAS: 54965-24-1
Molecular Weight: 563.7
Molecular Formula: C32H37NO8
Appearance: Clear
Physical State: Liquid

Terms: This product is intended for laboratory research use only. Read all terms and conditions of use before placing your order.

WARNING This product is a very potent chemical. This product is NOT for human use and can be harmful if ingested. This product is for research/laboratory use only. This product is NOT in a sterile solution and is NOT to be injected. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and should not be misbranded, misused or mislabeled as a drug, food or cosmetic.

The latter article is intended for educational / informational purposes only. THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

Additional information

Weight 2.3000 lbs